Michael Curran

Michael Curran

Company: MD Anderson Cancer Center

Job title: Associate Professor, Dept. of Immunology & Co-Founder, ORBIT Platform

Seminars:

Creating a Blockade of Myeloid Immune Checkpoints to Convert Radiotherapy into an Effective, Systemic Immunotherapy 9:00 am

• Discussing how radiotherapy triggers myeloid immune checkpoints that prevent tumor antigen cross-presentation • Demonstrating that blockade of these “don’t eat me signals” dramatically alters myeloid composition, phenotype, and T cell immune priming post-radiotherapy • Illustrating the mechanisms by which myeloid checkpoint blockade translates into systemic anti-tumor T cell responses that mediate regression of abscopal…Read more

day: Day Two

Functionally Repolarizing Myeloid Stroma with STING Agonist IMGS-203 to Eliminate Established Glioblastoma Tumors in Animal Models 3:00 pm

• Showing that potent, synthetic STING agonists like IMGS-203 functionally repolarize M2 macrophages and myeloid-derived suppressor cells • Modulating novel pathways including cMyc and cell metabolism • Demonstrating the capacity of IMGS-203 (IACS-8803) to regress otherwise immune-refractory murine models of glioblastoma Examining the potency of a related STING agonist, IACS-8779, to regress primary glioblastoma in…Read more

day: Day Two

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