Functionally Repolarizing Myeloid Stroma with STING Agonist IMGS-203 to Eliminate Established Glioblastoma Tumors in Animal Models

Time: 3:00 pm
day: Day Two


• Showing that potent, synthetic STING agonists like IMGS-203 functionally repolarize M2 macrophages and myeloid-derived suppressor cells

• Modulating novel pathways including cMyc and cell metabolism

• Demonstrating the capacity of IMGS-203 (IACS-8803) to regress otherwise immune-refractory murine models of glioblastoma Examining the potency of a related STING agonist, IACS-8779, to regress primary glioblastoma in client canines