Creating a Blockade of Myeloid Immune Checkpoints to Convert Radiotherapy into an Effective, Systemic Immunotherapy

Time: 9:00 am
day: Day Two


• Discussing how radiotherapy triggers myeloid immune checkpoints that prevent tumor antigen cross-presentation

• Demonstrating that blockade of these “don’t eat me signals” dramatically alters myeloid composition, phenotype, and T cell immune priming post-radiotherapy

• Illustrating the mechanisms by which myeloid checkpoint blockade translates into systemic anti-tumor T cell responses that mediate regression of abscopal tumor sites